Relationship between Spexin Neuropeptide and Cardiovascular Risk Factors in Children and Adolescents: A Systematic Review

Authors

  • Asghari, Golaleh Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran
  • Khorshidi, Yasaman Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran
  • Mirmiran, Parvin Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran
Abstract:

Introduction: Spexin, a novel neuropeptide with diverse physiological functions, can be a cardiovascular disease risk assessment biomarker. This study investigated the association between serum spexin concentration and cardiovascular risk factors in children and adolescents. Materials and Methods: A search was conducted to collect studies between January 2007 and March 2021 in the PubMed, Embase, and Scopus databases. The keywords "neuropeptide Q" and "spexin," along with keywords related to diabetes, inflammation, metabolic syndrome, and cardiovascular disease, were used for the search. Results: A total of 11 full-text articles were included in the study. In six of the studies, the spexin level was lower in obese children and adolescents than in normal-weight individuals, and the difference was significant in four of them (p <0.05). An inverse relationship was observed between spexin and insulin resistance in six of the studies; however, no correlation was found between spexin and glucose in the studies. The results were contradictory regarding inflammation, but the positive correlation of spexin with anti-inflammatory agents showed the anti-inflammatory effects of this neuropeptide. Five of the studies investigated the relationship between spexin and cardiovascular diseases such as hypertension, and three of them showed a positive role for spexin in cardiovascular health. Also, one of the studies examined the effect of spexin on metabolic syndrome and confirmed the protective role of spexin. Conclusion: It seems that this neuropeptide positively affects metabolic status, especially weight control and insulin resistance, in children and adolescents.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The Risk Factors of Prediabetes in Adolescents: A Systematic Review

Background: Pre-diabetes is a risk state for the future development of type 2 diabetes. The risk factors for prediabetes have been categorized as modifiable and non-modifiable. However, conclusive evidence regarding the risk factors associated with pre-diabetes in adolescence is still lacking. This study aims to answer the question of: which risk factors are most associated with the incidence o...

full text

Relationship between cardiovascular risk factors and adipokines in adolescents.

UNLABELLED This study evaluated the associations of adipokines with cardiovascular risk factors. SUBJECTS/METHODS 60 normal weight (BMI ≤75th percentile) and 60 overweight (BMI ≥95th percentile) adolescents aged 10-14 years. Resting systolic and diastolic blood pressures (SBP, DBP) and waist circumference were obtained in duplicate. Circulating adiponectin, resistin, tumor necrosis factor-α (...

full text

a comparative study of the relationship between self-, peer-, and teacher-assessments in productive skills

تمایل به ارزیابی جایگزین و تعویض آن با آزمون سنتی مداد و کاغذ در سالهای اخیر افزایش یافته است. اکثر زبان آموزان در کلاس های زبان از نمره نهایی که استاد تعیین میکند ناراضی اند. این تحقیق جهت بررسی ارزیابی در کلاس های زبان انگلیسی به هدف رضایتمندی زبان آموزان از نمره هایشان انجام گرفته است که در آن نمرات ارائه شده توسط سه گروه ارزیاب (ارزیابی خود دانشجو، همسالان واستاد) در مهارت های تولید (تکل...

15 صفحه اول

Sex education programs for children and adolescents: A Systematic Review

Sex education is considered as one of the main aspect of education that overlook in Iran. There were many challenges against application of sex education programs. We used systematic review for answering three questions related to definition and conceptualization of sex education, sex education curriculum and skills and investigating the effectiveness of these programs. Findings of this study s...

full text

the relationship between language and social capital in ilami kurdish: a sociopragmatic approach

چکیده زبان به عنوان یک وسیله در ایجاد و بازسازی سرمایه اجتماعی در چند دهه گذشته مورد توجه بوده است. اگر چه درباره سرمایه اجتماعی و سازه های مربوط به آن زیاد نوشته شده است ولی خیلی کم بر روی اینکه چطور زبان می تواند باعث ایجاد اعتماد یا بی اعتمادی بشود مطالعه ای انجام شده است. این مطالعه به منظور تحقق دو هدف انجام گرفته است. اول تلاش خواهد شد تا یک گونه شناسی از واژگانی که مردم کرد زبان شهر ا...

15 صفحه اول

Relationship between Anthropometric Measures and Cardiovascular Risk Factors in Children and Adolescents

BACKGROUND Obesity has been identified as an important risk factor in the development of cardiovascular diseases; however, other factors, combined or not with obesity, can influence cardiovascular risk and should be considered in cardiovascular risk stratification in pediatrics. OBJECTIVE To analyze the association between anthropometry measures and cardiovascular risk factors, to investigate...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 23  issue 3

pages  203- 215

publication date 2021-09

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023